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[texts]A novel de novo KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and M?bius syndrome. (Volume 20) - Ali, Zahra
This article is from Molecular Vision, volume 20.AbstractPurpose: To describe the phenotypic characteristics and clinical course of a sporadic case of congenital fibrosis of the extraocular muscles (CFEOM) and Möbius syndrome with a de novo mutation in the KIF21A gene encoding a kinesin motor protein. Methods: An individual with the rare combination of CFEOM and Möbius syndrome underwent comprehensive ophthalmologic and neurological evaluations...
[texts]Endophenotyping reveals differential phenotype-genotype correlations between myopia-associated polymorphisms and eye biometric parameters. (Volume 18) - Chen, Jian Huan
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the association with ocular biometric parameters in myopia-associated single nucleotide polymorphisms (SNPs) of the gap junction protein delta 2 (GJD2), insulin-like growth factor-1 (IGF1) and hepatocyte growth factor (HGF) genes in two geographically different Chinese cohorts. Methods: In 814 unrelated Han Chinese individuals aged above 50 years including 362 inland residents and 432 island dwellers, comprehensive ...
Downloads: 1
[texts]No association of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 or complement factor H polymorphisms with early age-related maculopathy in a Chinese cohort. (Volume 19) - Chen, Jian-Huan
This article is from Molecular Vision, volume 19.AbstractPurpose: Single nucleotide polymorphisms (SNPs) of age-related maculopathy susceptibility protein 2/HtrA serine peptidase 1 (ARMS2/HTRA1) and complement factor H (CFH) have been reported to be associated with age-related macular degeneration (AMD). The purpose of this study was to investigate the association of ARMS2/HTRA1 and CFH SNPs with early age-related maculopathy (ARM) in a Han Chinese cohort...
Downloads: 1
[texts]Novel mutations of the RS1 gene in a cohort of Chinese families with X-linked retinoschisis. (Volume 20) - Chen, Jieqiong
This article is from Molecular Vision, volume 20.AbstractPurpose: X-linked retinoschisis is a retinal dystrophy caused by mutations in the RS1 gene in Xp22.1. These mutations lead to schisis (splitting) of the neural retina and subsequent reduction in visual acuity in affected men (OMIM # 312700). The aim of this study was to identify the RS1 gene mutations in a cohort of Chinese patients with X-linked retinoschisis, and to describe the associated phenotypes...
Downloads: 3
[texts]Mutation analysis of paired box 6 gene in inherited aniridia in northern China. (Volume 19) - Chen, Peng
This article is from Molecular Vision, volume 19.AbstractPurpose: Aniridia is phenotypically and genetically heterogeneous. This study is to summarize the phenotypes and identify the underlying genetic cause of the paired box 6 (PAX6) gene responsible for aniridia in two three-generation Chinese families in northern China. Methods: A detailed family history and clinical data were collected from patients during an ophthalmologic examination...
Downloads: 1
[texts]Inhibition of VEGF expression and corneal neovascularization by shRNA targeting HIF-1? in a mouse model of closed eye contact lens wear. (Volume 18) - Chen, Peng
This article is from Molecular Vision, volume 18.AbstractPurpose: Inappropriate contact lens (CL) use and care often lead to corneal neovascularization (corneal NV). We used mouse eyes which wore CL as the animal model to assess the reason for corneal NV with CL wear. The similar and overlapping activity of vascular endothelial growth factor (VEGF) and the potent angiogenic hypoxia-inducible factor 1α (HIF-1α) called for a study of the temporal relationship in the expression of these two autoc...
Downloads: 2
[texts]Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy. (Volume 19) - Chen, Yabin
This article is from Molecular Vision, volume 19.AbstractPurpose: Dominant optic atrophy (DOA) is the most common form of autosomal inherited optic neuropathy, mainly caused by mutations in the optic atrophy 1 (OPA1) gene. The purpose of this study was to detect OPA1 gene mutations and associated phenotypes in Chinese patients with suspected hereditary optic neuropathy. Methods: A cohort of 193 Chinese families with suspected hereditary optic neuropathy was collected, which had been excluded fro...
Downloads: 1
[texts]Adrenomedullin22-52 suppresses high-glucose-induced migration, proliferation, and tube formation of human retinal endothelial cells. (Volume 20) - Chen, Zhigang
This article is from Molecular Vision, volume 20.AbstractPurpose: To investigate the roles of an adrenomedullin receptor antagonist (adrenomedullin22–52) on high-glucose-induced human retinal endothelial cell (HREC) in vitro cell biology. Methods: HRECs were cultured with different concentrations of glucose and adrenomedullin22–52. The proliferation of HRECs was evaluated by a cell counting kit-8 assay...
[texts]Aqueous cytokines as predictors of macular edema in non-diabetic patients following uncomplicated phacoemulsification cataract surgery. (Volume 19) - Chu, Liqun
This article is from Molecular Vision, volume 19.AbstractPurpose: To ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in non-diabetic patients following uncomplicated phacoemulsification cataract surgery. Methods: Undiluted aqueous humor samples were obtained from 288 consecutive non-diabetic patients (288 eyes; 132 men and 156 women) who underwent cataract surgery. Macular edema was defined as an increase in the foveal center point thickness (FCPT) more than 30% f...
Downloads: 1
[texts]ADP-ribosylation factor as a novel target for corneal neovascularization regression. (Volume 18) - Dai, Chunyan
This article is from Molecular Vision, volume 18.AbstractPurpose: To evaluate the roles of ADP-ribosylation factor (ARF) in alkali-induced corneal neovascularization (CNV). Methods: CNV was induced by alkali injury and compared in ARF1 inhibitor– or vehicle-treated mice 3 weeks after injury. Angiogenic and apoptosis factor expression in corneas after injury was quantified with reverse-transcription PCR...
Downloads: 2
[texts]Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs. (Volume 17) - Dong, Feng
This article is from Molecular Vision, volume 17.AbstractPurpose: The dopamine (DA) system in the retina is critical to normal visual development as lack of retinal DA signaling may contribute to myopic development. The involvement of DA in myopic development is complex and may be different between form deprivation and hyperopic defocus. This study evaluated effects of a non-selective DA receptor agonist, apomorphine (APO) on refractive development in guinea pigs treated with form deprivation o...
Downloads: 3
[texts]Identification of two novel LRP5 mutations in families with familial exudative vitreoretinopathy. (Volume 20) - Fei, Ping
This article is from Molecular Vision, volume 20.AbstractPurpose: To investigate the clinical features and disease-causing mutations in two Chinese families with familial exudative vitreoretinopathy (FEVR). Methods: Clinical data and genomic DNA were collected for patients with FEVR. The coding exons and adjacent intronic regions of FZD4, LRP5, TSPAN12, and NDP were amplified with PCR, and the resulting amplicons were analyzed with Sanger sequencing...
[texts]Novel mutation in FBN1 causes ectopia lentis and varicose great saphenous vein in one Chinese autosomal dominant family. (Volume 20) - Fu, Qing
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify genetic defects in a Chinese family with ectopia lentis (EL) and varicose great saphenous vein (GSV) and to analyze the correlations between phenotype and genotype. Methods: Twenty-two (12 affected subjects and ten unaffected subjects) among 53 members of a Chinese family underwent complete physical, ophthalmic, and cardiovascular examinations...
Downloads: 3
[texts]NGF promotes cell cycle progression by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation in human corneal epithelial cells. (Volume 18) - Hong, Jiaxu
This article is from Molecular Vision, volume 18.AbstractPurpose: Nerve growth factor (NGF) plays an important role in promoting the healing of corneal wounds. However, the molecular mechanism by which NGF functions is unknown. We investigated the possible effects of NGF on phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and mitogen activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) pathways and cell growth in human corneal epithelial cells (HCECs)...
Downloads: 2
[texts]Vascular endothelial growth factor A polymorphisms and age-related macular degeneration: a systematic review and meta-analysis. (Volume 19) - Huang, Chen
This article is from Molecular Vision, volume 19.AbstractPurpose: In the present work, the aim was to systematically review all studies about the association of vascular endothelial growth factor A (VEGF-A) polymorphisms with age-related macular degeneration (AMD) and to perform a meta-analysis. Methods: Relevant studies were searched using PubMed, Embase, Wanfang (Chinese), VIP (Chinese), and the Chinese National Knowledge Infrastructure databases up to October, 2011...
Downloads: 1
[texts]Detecting genetic variations in hereditary retinal dystrophies with next-generation sequencing technology. (Volume 20) - Jin, Xin
This article is from Molecular Vision, volume 20.AbstractPurpose: To identify pathogenic mutations responsible for retinal dystrophies (RDs) in three unrelated Chinese families. Methods: Three probands from unrelated families with RDs were recruited. Genomic DNA prepared from leukocytes was analyzed using gene chip–based next-generation sequencing (NGS) to capture and sequence all of the exons of 100 known RD-associated genes...
Downloads: 2
[texts]Calcium entry mediates hyperglycemia-induced apoptosis through Ca2+/calmodulin-dependent kinase ll in retinal capillary endothelial cells. (Volume 18) - Li, Jun
This article is from Molecular Vision, volume 18.AbstractPurpose: Hyperglycemia-induced vascular cell apoptosis is a seminal early event in diabetic retinopathy. Prolonged hyperglycemia is known to increase intracellular cytosolic free calcium ([Ca2+]i) in retinal vascular endothelial cells (RECs), suggesting that [Ca2+]i is a critical trigger for microvascular degeneration. This study aims to elucidate Ca2+-dependent signaling mechanisms that mediate hyperglycemia-induced apoptosis in RECs...
Downloads: 1
[texts]An updated meta-analysis: Apolipoprotein E genotypes and risk of primary open-angle glaucoma. (Volume 20) - Liao, Rongfeng
This article is from Molecular Vision, volume 20.AbstractPurpose: To study the association of apolipoprotein E (APOE) polymorphisms and primary open-angle glaucoma (POAG). Methods: After a systematic literature search, all relevant studies evaluating the association between APOE polymorphisms and POAG were included. All statistical tests were calculated with Stata 11.0. Results: Twelve independent studies on the APOE gene (1,971 cases, 1,756 controls) and POAG were included...
Downloads: 2
[texts]Amniotic membrane traps and induces apoptosis of inflammatory cells in ocular surface chemical burn. (Volume 18) - Liu, Ting
This article is from Molecular Vision, volume 18.AbstractPurpose: Severe chemical burns can cause necrosis of ocular surface tissues following the infiltration of inflammatory cells. It has been shown that amniotic membrane transplantation (AMT) is an effective treatment for severe chemical burns, but the phenotypes of cells that infiltrate the amniotic membrane and the clinical significance of these cellular infiltrations have not previously been reported...
Downloads: 3
[texts]The tear film characteristics of spontaneous subconjunctival hemorrhage patients detected by Schirmer test I and tear interferometry. (Volume 18) - Liu, Wei
This article is from Molecular Vision, volume 18.AbstractPurpose: To evaluate the tear film characteristics of spontaneous subconjunctival hemorrhage patients by Schirmer test I and tear interferometry. Methods: Forty-six spontaneous subconjunctival hemorrhage patients and 46 controls were enrolled in the study. Schirmer test I and tear interferometry were performed in all 92 subjects. The results obtained were compared between the two groups...
Downloads: 2
[texts]Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice. (Volume 18) - Liu, Yong
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate the effects of topical FTY720 and cyclosporin A (CsA) on allogeneic corneal transplantation in mice. Methods: A total of 75 BALB/c mice received corneal grafts from C57BL/6 donors. Recipients were treated with 0.1%, 0.3%, or 0.5% FTY720 ophthalmic gel or 1% CsA eye-drops after the graft (controls received no treatment)...
Downloads: 1
[texts]Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. (Volume 17) - Luo, Chang
This article is from Molecular Vision, volume 17.AbstractPurpose: To understand the expression of genes involved in different complement pathways in the retina and retinal pigment epithelium (RPE)/choroid under physiologic conditions and how their expression is regulated by inflammatory cytokines. Methods: The expression of complement components of the classical pathway (CP), mannose-binding lectin (MBL) pathway, alternative pathway (AP), and terminal pathway in the retina and RPE/choroid was de...
Downloads: 3
[texts]Meta-analysis of association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-?2 gene and diabetic retinopathy in Caucasians and Asians. (Volume 18) - Ma, Jinlan
This article is from Molecular Vision, volume 18.AbstractPurpose: The Pro12Ala polymorphism of the peroxisome proliferator–activated receptor-γ2 (PPARγ2) gene is reported to be associated with diabetes. However, the gene’s association with diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) has been investigated in numerous epidemiologic studies with controversial results. This meta-analysis aimed to collectively assess the association of the Pro12Ala polymorphism with DR in T2DM...
Downloads: 2
[texts]Adnotationes et meditationes in Euangelia quae in sacrosancto Missae sacrificio toto anno leguntur : cum eorundem Euangeliorum concordantia - Nadal, Gerónimo, 1507-1580
Engraved t.p
Keywords: Jesus Christ; Bible; Bible
Downloads: 56
[texts]Mutation analysis of pre-mRNA splicing genes in Chinese families with retinitis pigmentosa. (Volume 20) - Pan, Xinyuan
This article is from Molecular Vision, volume 20.AbstractPurpose: Seven genes involved in precursor mRNA (pre-mRNA) splicing have been implicated in autosomal dominant retinitis pigmentosa (adRP). We sought to detect mutations in all seven genes in Chinese families with RP, to characterize the relevant phenotypes, and to evaluate the prevalence of mutations in splicing genes in patients with adRP. Methods: Six unrelated families from our adRP cohort (42 families) and two additional families with...
Downloads: 3
[texts]Mutational screening of six genes in Chinese patients with congenital cataract and microcornea. (Volume 17) - Sun, Wenmin
This article is from Molecular Vision, volume 17.AbstractPurpose: To identify mutations in 6 genes of 9 Chinese families with congenital cataract and microcornea. Methods: Nine unrelated families with congenital cataract and microcornea were collected. Cycle sequencing was used to detect variants in the coding and adjacent regions of the crystallin alpha A (CRYAA), crystallin beta B1 (CRYBB1), crystallin beta A4 (CRYBA4), crystallin gamma C (CRYGC), crystallin gamma D (CRYGD), and gap junction p...
[texts]Mutation analysis of 12 genes in Chinese families with congenital cataracts. (Volume 17) - Sun, Wenmin
This article is from Molecular Vision, volume 17.AbstractPurpose: To identify mutations in 12 genes in Chinese families with congenital cataracts. Methods: Twenty five families with congenital cataracts involved in this study. The coding exons and adjacent intronic regions of 12 genes were analyzed by cycle sequencing, including the alpha A crystallin (CRYAA), alpha B crystallin (CRYAB), beta A1 crystallin (CRYBA1), beta A4 crystallin (CRYBA4), beta B1 crystallin (CRYBB1), beta B2 crystallin (CR...
Downloads: 1
[texts]Retinol dehydrogenase 13 protects the mouse retina from acute light damage. (Volume 18) - Wang, Haiyan
This article is from Molecular Vision, volume 18.AbstractPurpose: To investigate whether retinol dehydrogenase 13 (RDH13) can protect the retina from acute light-induced damage. Methods: We generated Rdh13 knockout mice using molecular biologic methods and assessed the associated morphological and functional changes under room-light conditions by hematoxylin-eosin (H&E), transmission electron microscopy (TEM), and scotopic electroretinography...
Downloads: 2
[texts]Protective effect of paeoniflorin against oxidative stress in human retinal pigment epithelium in vitro. (Volume 17) - Wankun, Xie
This article is from Molecular Vision, volume 17.AbstractPurpose: This study was conducted to determine whether paeoniflorin (PF) could prevent H2O2-induced oxidative stress in ARPE-19 cells and to elucidate the molecular pathways involved in this protection. Methods: Cultured ARPE-19 cells were subjected to oxidative stress with H2O2 in the presence and absence of PF. The preventive effective of PF on reactive oxygen species (ROS) production and retinal pigment epithelium (RPE) cell death induc...
Downloads: 2
[texts]Genoprotective effect of hyaluronic acid against benzalkonium chloride-induced DNA damage in human corneal epithelial cells. (Volume 17) - Wu, Han
This article is from Molecular Vision, volume 17.AbstractPurpose: The aim of this study was to investigate hyaluronic acid (HA) protection on cultured human corneal epithelial cells (HCEs) against benzalkonium chloride (BAC)-induced DNA damage and intracellular reactive oxygen species (ROS) increase. Methods: Cells were incubated with different concentrations of BAC with or without the presence of 0.2% HA for 30 min...
[texts]Retinal whole genome microarray analysis and early morphological changes in the optic nerves of monkeys after an intraorbital nerve irradiated injury. (Volume 17) - Xia, Yong
This article is from Molecular Vision, volume 17.AbstractPurpose: To obtain and analyze early retinal changes at the molecular level 24 h after a radiation injury to the ipsilateral intraorbital nerve using gamma knife surgery (GKS), and to examine the morphological changes in bilateral optic nerves. Methods: Unilateral intraorbital optic nerves of three rhesus macaques were treated by GKS with irradiated doses of 15 Gy, while contralateral optic nerves and retinas served as the control...
Downloads: 4
[texts]NOD2/CARD15 gene mutation identified in a Chinese family with Blau syndrome. (Volume 18) - Xiang, Haotian
This article is from Molecular Vision, volume 18.AbstractPurpose: To characterize the clinical features of a Chinese pedigree with Blau syndrome and to identify mutations in the NOD2/CARD15 (nucleotide-binding oligomerization domain containing 2/caspase recruitment domain family, member 15) gene. Methods: Clinical features of this family were evaluated. Genomic DNA was obtained from blood samples, and all exons of NOD2/CARD15 were amplified by polymerase chain reaction (PCR) and direct DNA seque...
Downloads: 1
[texts]New ZNF644 mutations identified in patients with high myopia. (Volume 20) - Xiang, Xinying
This article is from Molecular Vision, volume 20.AbstractPurpose: Myopia, or near-sightedness, is one of the most common human visual impairments worldwide, and high myopia is one of the leading causes of blindness. In this study, we investigated the mutation spectrum of ZNF644, a causative gene for autosomal dominant high myopia, in a high-myopia cohort from a Chinese population. Methods: DNA was isolated with the standard proteinase K digestion and phenol-chloroform method from a case cohort o...
Downloads: 4
[texts]Cerulean cataract mapped to 12q13 and associated with a novel initiation codon mutation in MIP. (Volume 17) - Xiao, Xueshan
This article is from Molecular Vision, volume 17.AbstractPurpose: To identify the genetic defect in a large Chinese family with autosomal dominant cerulean cataract. Methods: Genomic DNA and clinical data were collected from the family. Candidate gene sequencing and genome-wide linkage analysis were used to disclose the molecular basis responsible for cerulean cataract in the family. Results: Initially, sequencing analysis of the three genes (beta-B2-crystallin [CRYBB2], gamma-D-crystallin [CRYG...
Downloads: 1
[texts]A recurrent mutation in GUCY2D associated with autosomal dominant cone dystrophy in a Chinese family. (Volume 17) - Xiao, Xueshan
This article is from Molecular Vision, volume 17.AbstractPurpose: To identify the genetic locus and mutation responsible for autosomal dominant cone dystrophy (adCOD) in a large Chinese family and to describe the phenotypes of the patients. Methods: Genomic DNA and clinical data were collected from the family. Genome-wide linkage analysis was performed to map the disease locus, and Sanger dideoxy sequencing was used to detect the mutation in a candidate gene...
Downloads: 1
[texts]Interleukin-4 and melatonin ameliorate high glucose and interleukin-1? stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells. (Volume 20) - Xie, Manyun
This article is from Molecular Vision, volume 20.AbstractPurpose: We aimed to evaluate the effects of two immune regulatory factors, interleukin-4 (IL-4) and melatonin, on several inflammatory mediators that are involved in inflammation and angiogenesis in diabetic retinopathy (DR), in high glucose or interleukin-1β (IL-1β) induced primary human retinal endothelial cells (RECs) and human retinal pigment epithelial (RPE) cells...
Downloads: 5
[texts]Gene regulation by PAX6: Structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204. (Volume 20) - Xie, Qing
This article is from Molecular Vision, volume 20.AbstractPurpose: Pax6 is a key regulatory gene for eye, brain, and pancreas development. It acts as a transcriptional activator and repressor. Loss-of-function of Pax6 results in down- and upregulation of a comparable number of genes, although many are secondary targets. Recently, we found a prototype of a Pax6-binding site that acts as a transcriptional repressor...
Downloads: 1
[texts]Roles of tumor necrosis factor alpha gene polymorphisms, tumor necrosis factor alpha level in aqueous humor, and the risks of open angle glaucoma: A meta-analysis. (Volume 19) - Xin, Xiangyang
This article is from Molecular Vision, volume 19.AbstractPurpose: This meta-analysis was performed to clarify the association between tumor necrosis factor alpha (TNF-α) gene polymorphisms and open angle glaucoma (OAG) risks, and the association between the TNF-α level in aqueous humor (AH) and the risks of glaucoma. Methods: A computerized literature search was performed for the relevant available studies from three databases including PubMed, ISI Web of Science, and Embase...
Downloads: 2
[texts]Novel RPE65 mutations associated with Leber congenital amaurosis in Chinese patients. (Volume 18) - Xu, Fei
This article is from Molecular Vision, volume 18.AbstractPurpose: Retinal pigment epithelium-specific protein 65 kDa (RPE65) plays an essential role in vitamin A metabolism necessary for synthesizing the visual pigment 11-cis-retinal chromophore. Mutations in RPE65 cause the childhood blindness disorder known as Leber congenital amaurosis (LCA), as well as autosomal recessive retinitis pigmentosa (RP)...
Downloads: 6
[texts]Increased importin 13 activity is associated with the pathogenesis of pterygium. (Volume 19) - Xu, Ke
This article is from Molecular Vision, volume 19.AbstractPurpose: We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism incl...
Downloads: 1
[texts]Spectrum of rhodopsin gene mutations in Chinese patients with retinitis pigmentosa. (Volume 20) - Yang, Guoxing
This article is from Molecular Vision, volume 20.AbstractPurpose: This study was to analyze the spectrum and frequency of rhodopsin gene (RHO) mutations in Chinese patients with retinitis pigmentosa (RP). Methods: Patients were given physical examinations, and blood samples were collected for DNA extraction. The RHO mutations were screened with direct sequencing. Results: Eight heterozygous nucleotide changes were detected in eight of 300 probands with RP, including six novel mutations and two k...
Downloads: 3
[texts]Identification of FZD4 and LRP5 mutations in 11 of 49 families with familial exudative vitreoretinopathy. (Volume 18) - Yang, Huiqin
This article is from Molecular Vision, volume 18.AbstractPurpose: To identify mutations in FZD4 and LRP5 in 49 Chinese families with familial exudative vitreoretinopathy (FEVR) and to reveal the mutation spectrum and frequency of these genes in the Chinese population. Methods: Clinical data and genomic DNA were collected for patients from 49 families with FEVR. The coding exons and adjacent intronic regions of FZD4 and LRP5 were amplified with polymerase chain reaction, and the resulting amplico...
Downloads: 1
[texts]Inhibition of p38 mitogen-activated protein kinase phosphorylation decrease tert-butyl hydroperoxide-induced apoptosis in human trabecular meshwork cells. (Volume 18) - Yang, Yuxia
This article is from Molecular Vision, volume 18.AbstractPurpose: Oxidative stress induced trabecular meshwork cells death is believed to be involved in the pathogenesis and progression of primary open-angle glaucoma (POAG). However, the intrinsic mechanism is yet to be clarified. This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert-butyl hydroperoxide (tBHP)-induced apoptosis of human trabecular meshwork (iHTM) cells...
Downloads: 2
[texts]Pharmacokinetics and retinal toxicity of various doses of intravitreal triamcinolone acetonide in rabbits. (Volume 20) - Ye, You-Fan
This article is from Molecular Vision, volume 20.AbstractPurpose: To compare the pharmacokinetics and retinal toxicity of various doses of intravitreal triamcinolone acetonide (TA) in rabbits. Methods: The rabbits received intravitreal injections of 4 mg and 8 mg TA. The drug concentrations were determined with high-performance liquid chromatography after extraction from the vitreous at various time points...
Downloads: 2
[texts]Congenital polymorphic cataract associated with a G to A splice site mutation in the human beta-crystallin gene CRYβA3/A1. (Volume 18) - Yu, Yibo
This article is from Molecular Vision, volume 18.AbstractPurpose: To identify the underlying genetic defect in four generations of a Chinese family affected with bilateral congenital polymorphic cataracts. Methods: Family history and clinical data were recorded. The phenotype was documented using slit-lamp photography. Genomic DNA samples were extracted from peripheral blood of family members. Candidate genes were amplified using polymerase chain reaction (PCR) and screened for mutations on both...
Downloads: 1
[texts]Complement factor H Val62Ile variant and risk of age-related macular degeneration: A meta-analysis. (Volume 19) - Yuan, Dongqing
This article is from Molecular Vision, volume 19.AbstractPurpose: To evaluate the precise association of complement factor H (CFH) Val62Ile polymorphism with age-related macular degeneration (AMD) susceptibility. Methods: We performed a meta-analysis using databases including PubMed, EMBASE, and Web of Science to find relevant studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed-effect and random-effects models...
Downloads: 1
[texts]A gene expression profile of the developing human retinal pigment epithelium. (Volume 18) - Zhang, Zhongyu
This article is from Molecular Vision, volume 18.AbstractPurpose: The molecular mechanisms associated with human retinal pigment epithelium (RPE) development constitute the basis for cell replacement therapy for the treatment of retinal degenerative diseases. In the current study, gene expression analysis of the human fetal RPE during development was performed and was compared with the human native RPE...
Downloads: 2
[texts]A novel splice site mutation in the COL4A5 gene in a Chinese female patient with rare ocular abnormalities. (Volume 18) - Zhao, Chan
This article is from Molecular Vision, volume 18.AbstractPurpose: To describe an unusual ocular phenotype in a Chinese female patient with X-linked Alport syndrome (XLAS), and to characterize the type IV collagen alpha 5 (COL4A5) gene mutation in the patient and her son. Methods: Detailed ophthalmologic examinations and optical coherence tomography were performed in the patient and her family members...
Downloads: 2
[texts]The role of SLIT-ROBO signaling in proliferative diabetic retinopathy and retinal pigment epithelial cells. (Volume 17) - Zhou, Weiyan
This article is from Molecular Vision, volume 17.AbstractPurpose: SLIT-ROBO signaling acts as a cue in neuronal guidance and plays a role in vasculogenesis and angiogenesis. The aim of this study is to explore the effects of robo1 and slit2 on the formation of fibrovascular membranes (FVMs) in samples from patients with proliferative diabetic retinopathy. The effects of advanced glycation end products (AGEs) on robo1 and slit2 expression in human retinal pigment epithelium (RPE) cells and the ro...
[texts]Synthesis of thiolated chitosan and preparation nanoparticles with sodium alginate for ocular drug delivery. (Volume 18) - Zhu, Xuan
This article is from Molecular Vision, volume 18.AbstractPurpose: The goal of the present study was to synthesize mucoadhesive polymer – thiolated chitosan (TCS) from chitosan (CS), then prepared CS/TCS-sodium alginate nanoparticles (CS/TCS-SA NPs), determined which was more potential for ocular drug delivery. Methods: A new method for preparing TCS was developed, and the characteristics were determined using Fourier transform infrared spectroscopy and the degree of thiol immobilized was measu...
Downloads: 2
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